The Central Ohio Practice-Based Research Network (COPBRN) consists of 83 primary care sites – 9 family medicine sites of the Ohio State University Primary Care Network, including one shared site with general internal medicine; 5 Ohio State University Division of General Internal Medicine sites; 9 PrimaryOne Health, Inc. sites; 11 Nationwide Children’s Hospital Pediatric Primary Care Centers; and 49 Central Ohio Primary Care sites. This collaborative of clinical networks serves to maximize the diversity, breadth, and depth of the available primary care study populations in Central Ohio and represents the diverse demographics of the region. The COPBRN is committed to the performance of high quality practice-based research in order to add to the primary care knowledge base, enhance the delivery of preventive medicine, and positively influence diagnosis and treatment of the health problems of patients, families, and communities. The COPBRN is a member of the Agency for Health Research & Quality (AHRQ) PBRN registry and is a member of the Collaborative Ohio Inquiry Network (COIN), a designated Center of Excellence for Primary Care Practice-Based Research and Learning Networks (PCPRLN) recognized by AHRQ. The COPBRN is administratively housed in the Department of Family Medicine at the Ohio State University and is led by a Steering Committee including representatives from each of the member clinical networks.