1974 – The 474 bill is passed by Ohio's 110th General Assembly to create departments of family medicine in Ohio's colleges and universities, which had medical schools. 
Academic family medicine is initiated at The Ohio State University as a division of the Department of Preventive Medicine. P. Tennyson Williams, MD, is recruited from private practice and appointed Professor and Chair.
The Department of Family Medicine receives full accreditation for its Family Practice Residency Program, the first university-based family practice residency program in Ohio.
1975 – The Department of Family Medicine is established as an independent academic department within The Ohio State University College of Medicine. The Department of Family Medicine begins offering elective, third-year and fourth-year medical student rotations.
1980 – The Physical Examination course is developed and implemented for all Independent Study Pathway students (now also offered to all Problem-based Learning Pathway students). The Department of Family Medicine establishes the Fellowship Program to train future family physician academicians.
1981 – The Department of Family Medicine establishes the International Fellowship Program.
1986 – The Department of Family Medicine’s third-year medical student clerkship is made a requirement for all medical students by the College’s Executive Curriculum Committee.
1987 – The Department of Family Medicine establishes the East Central HIV/AIDS Education and Training Center (ECAETC) serving Ohio, Michigan, Kentucky, and Tennessee.
1990 – John A. Lombardo, MD, is appointed Professor and Chair of the Department of Family Medicine. He initiates sports medicine as a major clinical emphasis of the Department.
1992 – Sports Medicine is established in the Department of Family Medicine in conjunction with the Department of Orthopaedics. The Center of Sports Medicine is established with a primary responsibility to care for over 800 Division I NCAA athletes participating in 36 varsity teams at The Ohio State University. Sports medicine care is provided at practice sessions, at sporting events, through training room supervision, and as necessary, through hospital care.
1995 – The Rardin Family Practice Center opens. The center is named to honor Thomas E. Rardin, MD, one of the leaders in Ohio who helped establish family practice nationally as a recognized medical specialty. 
Glen F. Aukerman, MD, is appointed Professor and Chair of the Department of Family Medicine. He expands the Department of Family Medicine’s clinical presence to several locations throughout central Ohio.
1998 – The Ohio State University Family Medicine Rural Residency Track is established. It is one of less than 30 unique rural training track graduate medical education programs across the country, and the first "2-2-2" integrated RTT. Since June 2000, the program has graduated numerous physicians, all of whom are serving in rural or underserved communities.
1999 – Mary Jo Welker, MD, is appointed Professor and Chair of the Department of Family Medicine. She brings balanced emphasis to what it means for The Ohio State University Department of Family Medicine to be part of a major land grant institution.
2000 – The Department of Family Medicine establishes interdisciplinary Ohio State Primary Care Academic Institute.
2002 – The Department of Family Medicine launches a pilot initiative, the computer-based Interactive Guide to Physical Examination for second-year students. This web-based technology is recognized for revolutionizing medical education. 
2003 – The Department of Family Medicine introduces the Urban Family Medicine Track to its residency program. The new program aims to address the needs of urban communities that have barriers to quality healthcare. This is one of the first programs of its kind in the United States to gear resources specifically for an urban population.
2004 – The Department of Family Medicine introduces the Academic Medicine Track to its residency program. The new program prepares family practice residents for a career in academic family medicine, with a focus on teaching, leadership and scholarship/research.
2005 – Integrative Medicine established in the Department of Family Medicine with the Center of Integrative Medicine opened to offer healthcare services and education not often found in traditional Western medical centers. The Center incorporates the art and science of caring for the whole person – body, mind and spirit – to treat and prevent disease, encouraging patients to create a condition of optimal health and providing an evidence-based, patient-centered approach to holistic health care.
2007 – MedShow goes live! An Internet portal designed to reach today’s youth and the public to increase awareness of the essential need for family physicians plus to promote Family Medicine to premedical and medical students. Created through a partnership of 2Under Entertainment and the Ohio State Department of Family Medicine, founding collaborators include the Ohio State University Medical Center, the Ohio Academy of Family Physicians, and the American Academy of Family Physicians.
2008 – Electronic Medical Record (EMR) implemented in all Family Medicine practice sites as a lead to implementation of outpatient EMR system in all ambulatory sites of other specialties at the Medical Center.